6. Licorice Root
True licorice root—not just the candy flavoring—contains glycyrrhizin, which can cause your body to retain sodium and lose potassium, leading to increased blood pressure and fluid retention. This effect can undermine the blood pressure control achieved by amlodipine.
Licorice root is sometimes found in herbal teas and supplements. If you regularly consume these products, check ingredient labels carefully. Avoiding licorice root-containing products is recommended to prevent interference with your medication.
7. St. John’s Wort
St. John’s Wort is an herbal supplement frequently used for mood support. It induces liver enzymes, particularly CYP3A4, which increases the metabolism of amlodipine, lowering its concentration in your blood. This interaction can reduce the drug’s effectiveness, leading to inadequate blood pressure control.
If you take St. John’s Wort, speak with your healthcare provider. They may need to adjust your amlodipine dosage or recommend alternative treatments to ensure your blood pressure remains well managed.
8. Dehydration
Dehydration reduces blood volume and can cause your blood pressure to become unstable, increasing the risk of dizziness, headaches, and fainting when on amlodipine. Because amlodipine dilates blood vessels, adequate hydration is crucial to maintain effective circulatory function.
Signs of dehydration include dry mouth, dark-colored urine, and fatigue. Aim to sip water consistently throughout the day rather than waiting until you feel thirsty to maintain stable blood pressure and reduce side effects.
